The structure of our DNA is constantly tested by the influence of endogenous and environmental factors. The damage caused is a source of cellular dysfunction. In fact, if these DNA modifications are not repaired, they can have serious consequences on our health: amplification of apoptosis (cell death), increase in carcinogenesis, acceleration of senescence, etc. To counteract these phenomena, our organism has implemented two main types of repairs: homologous recombination: repairs DNA breaks using homologous sequences of undamaged chromatids. In mammals it plays an essential role in cell division phenomena (meiosis, mitosis) and its inactivation leads to the development of tumors by increasing the sensitivity of cells to mutagenic agents. Non-homologous recombination: consists of directly gluing together the broken ends of DNA without respecting the homology of the sequences. This repair risks generating mutations capable of directing cells towards a tumor phenotype. During aging, the trend of different repair modalities changes in modo very significant. Indeed, the homologous repair mode would be abandoned in favor of non-homologous recombination. These changes lead to an accumulation of mutations and therefore to an increase in cellular and tissue anomalies. DNA-PKASE allows us to counteract these phenomena by acting at the level of different regulatory axes such as: The preservation of genomic integrity, thanks to the presence of vanilla extracts which allow us to repress the inducers of DNA damage and stimulate homologous repair at the expense of non-homologous recombination. Enhancement of anti-tumor effects and elimination of anarchic cells thanks to the presence of Cinchona officinalis extract. 100% natural origin supplement.
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