Since the metabolism of individuals is variable, it is advisable to adapt the doses according to the personalized recommendations of the healthcare professional. At a biochemical level, the physiological translation of the sensation of pleasure corresponds, among other things, to the release of β-endorphin. This molecule degrades very quickly. This is one of the reasons why pleasure is always perceived fleetingly. Other neurohormones involved in the perception of sensations are rapidly degraded by various vie enzymatic (COMT and MAO*, leading to a common final product: VMA, or vanillyl-mandelic acid, a molecule very close to vanillin (the natural flavor of vanilla). , antidepressant treatments act mainly both on slowing down the degradation of neurohormones , and on the inhibition of their reuptake.The oily organic extract of Flos salis, added to a culture of keratinocytes (epidermal cells extracted from human skin), increases the synthesis of β-endorphin from keratinocytes. These results have been confirmed ex vivo on organotypic cultures that demonstrate the stimulation of β-endorphin production by the epidermis, after topical application with a cream enriched with fleur de sel oily extract. Cyclotelia contains Flos salis oily extract which improves the release of β-endorphin, Padina pavonica algae extract which stabilizes β-endorphin by improving the production of heparan sulphate and keratan sulphate as well as tahitensis vanilla extract which enhances β-endorphin produced by human keratinocytes. This food supplement is of interest in the mechanisms of regulation of the sensorial, emotional and behavioral response, following physical, mental, chemical, thermal stress... COMT Catechol-O methyl transferase and MAO: monoamine oxidase. Hence the inhibition of these vie degradation by MAOIs (MAO inhibitors) in the treatment of depression.
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